Every year the MEDLINE data is reloaded, complete with the updated version of the MeSH thesaurus. This process is due to start this week. During the reload, no updates to the MEDLINE database will be made. Therefore November week 3, 2010 will be the final update, until the reload is completed. This is expected to occur in mid-December, however previous experience has shown that it may be mid-January until new updates are provided.
No data is lost during the reload process, the first update after the reload will just be larger than normal. Therefore if you have any auto-alerts set up, you will notice a break in provision, followed by an abnormally large alert.